![]() Posaconazole (Noxafil®) is a broad-spectrum triazole used to prevent and treat invasive mycoses due to Candida sp. In majority of cases, posaconazole was not compatible with drugs having alkaline pH, commonly used in a hematology unit. On the 19 drugs tested, only filgrastim and tacrolimus showed no visual change with posaconazole during a 4-h storage. Seventy two mixtures have been realised: 55.56% of pairs (n=40/72) resulted in a precipitation, against 44.44% (n=32/72) with no visual modification after a 4-h storage. Visual evaluations were performed after the mixture, after one and 4 h. ![]() ![]() For each pair studied, three different ratios were prepared (9:1, 1:1, 1:9). In the absence of compatibility data, the physical compatibility was tested for each pair including one of the 24 solutions and posaconazole. A total of 24 solutions were produced (not including the posaconazole). For some drugs, different conditions have been tested. The most widely used injectable drugs co-administered with posaconazole have been listed with a total of 19 drugs. The objective of this work was to study the physical compatibility of injectable posaconazole with other drugs commonly used in an adult hematology care unit. Concomitant administration of two incompatible drugs in the same infusion line can lead to a precipitation which could have clinical consequences for patients.
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